| abstract |
The present invention relates to novel compounds for the inhibition of blood coagulation proteins, and more particularly to derivatives of malonic acid of the formula (1), wherein R (1), R (2) and R (3) , R (4), R (5), and R (6) have the meanings indicated in the claims. The compounds of the formula (I) are inhibitors of the blood coagulation enzyme, factor Xa. The invention also relates to processes for the preparation of the compounds of the formula (I), methods for inhibiting the activity of factor Xa and for -inhibiting blood clotting, to the use of the compounds of the formula (I) in the treatment and prophylaxis of diseases that can be treated or prevented by the inhibition of factor Xa activity such as thromboembolic diseases, and the use of the compounds of formula (I) in the preparation of drugs to be applied in diseases of this type . The invention also relates to compositions containing a compound of the formula (I) in mixtures or in association in another way with an inert carrier, in particular pharmaceutical compositions containing a compound of the formula (I) together with pharmaceutically acceptable carriers. and pharmaceutically acceptable auxiliary substances. |