| abstract |
The invention relates to a compound of the formula (I), wherein R 1 is a sugar; R2 is -CH2-O- (R7) m, R7 representing a sugar, or R2 is -COOH; R3 is a group containing epoxide, C1-C6 alkyl or C2-C6 alkenyl, unsubstituted or substituted by at least one OH; R5 is H, C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl; R4, R6, R8 and R10 independent of each other are H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, -X2H or -X2R12, or R4 and R6 together and / or R8 and R10 together are = X2; X2 is o, NH, N-Cl-CG alkyl, C2-C6 N-alkenyl, C2-C6 N-alkynyl or S; R12 is C1-C6 alkenyl, C2-C6 alkynyl, C2-C6 alkynyl, aryl or acyl; and m and n are 1 or 2; and its physiologically acceptable salts. The compounds can be obtained from a culture of the actinomycetal microorganism species HAG 003959, DSM 12931, by fermentation. Accordingly, the invention relates to a process for its preparation and the use of the compounds as pharmaceuticals, for example as anti-tumor compounds. |