| abstract |
The compounds of formula (la) or (lb) or salts thereof, wherein Z is N or CH; where n is 0 or 1; X1 and X2 are linkers; Ar represents one or two substituted or unsubstituted aromatic or heteroaromatic rings, and Cy represents one or two substituted or unsubstituted cyclic or heterocyclic portions, or consists of a substituted or unsubstituted cyclic or heterocyclic portion and a substituted or unsubstituted aromatic or heteroaromatic portion substituted, Y is O, S, NR or CR2 wherein R is H or (1-6C) alkyl; every 11 and 12 is independently 0-4; 13 is 0 or 1; each of R1, R2 and R3 is independently alkyl (1-6C), aryl (6-10C) or arylalkyl (7-16C) which optionally contains 1-4 heteroatoms selected from the group consisting of halogen, N, P , O, and S or independently may be halogen, OR, SR, NR2, OOCR, NROCR, COR, COOR, CONR2, CF3, CN or NO2, where R is H or alkyl (1-6C), and where Dotted lines represent optional n-bonds, or compounds of formulas (la) or (lb) where (X2) nAr or (X2) nCy is replaced by alkyl (1-6C) and are useful in the methods for. block sodium channels. (see formula). |