| abstract |
The compounds of the formula (1) (see formula) and their salts, in which Cy represents cyclohexyl; Y is CH = Chzeta L, CHzeta2 ,, zeta or Cy, X is trivalent straight chain alkylene (3-10C) or straight chain trivalent 1-alkenylene (3-10C) optionally substituted by oxo in C adjacent to N, when n is 0 and Y is zeta2 CH; and is otherwise trivalent straight chain alkylene (5-10C) or 1-alquelidene (5-10C) optionally substituted by oxo in C adjacent to N; Z is N, NCO, CHNCOR1 or -CHNR1, in which R1 is alkyl (1-6C) and by halogen, CF3, OCF3, NO2, NR2, OR, SR, COR, COOR, CONR2, NROCR or OOCR, in which R is H or alkyl (1-4C), or two substituents can form a 5-7 membered ring, with the proviso that the compounds of the formula (1) contain at least one aromatic portion, are useful as channel blockers of calcium |