| abstract |
A compound of the formula (1) and pharmaceutically acceptable hydrolysable salts, solvates and esters thereof are described, wherein: X1 represents O or S; R1 and R2 independently represent H, halogen, -CH3 and -OCH3; n represents 1 or 2; X2 represents NH, NCH3 or O; one of Y and Z is N, and the other is O or S; R3 represents phenyl or pyridyl (where N is in position 2 or 3) and is optionally substituted by one or more of halogen, NO2, NH2, CF3, OCF3, straight or branched alkyl of OC1-6, alkyl, alkenyl or alkynyl straight or branched C1-6 provided that when R3 is pyridyl, the N is not substituted; R4 represents CF3 or CH3- (see formula). |