| abstract |
This invention provides novel compounds and methods and compositions that use them, in the treatment of diseases of the central nervous system, which includes depression and anxiety, the compounds have the formula (I) (see formula) wherein Ar is an aryl group, arylalkyl or heteroaryl; R1 and R2 are independently selected from hydrogen, alkyl of 1 to 12 carbon atoms that may be substituted or cycloalkyl of 3 to 10 carbon atoms that may be substituted; R3 is H, alkyl which may be substituted, cyclic alkyl which may be substituted, halogen, alkoxy, haloalkyl, OH, nitro, amino, CN, carboxy, alkoxycarbonyl, alkylcarbonyl, aminocarbonyl and alkylaminocarbonyl; or a pharmaceutically acceptable salt thereof. |