| abstract |
The present invention relates to non-peptide factor Xa inhibitors which are useful for the treatment of arterial occlusive and thrombotic venous disorders, inflammation, cancer and neurodegenerative diseases. - Factor Xa inhibitors provide compounds that have formula (I) or pharmaceutically acceptable salts thereof; wherein Q is phenyl, benzyl, pyridyl, thienyl, indolyl, quinolinyl, benzothienyl, biphenyl or imidazolyl; any of which may include one or more optional substituents that are independently selected from halo, trifluoromethyl, .hydroxy, amino, nitro, cyano, alkoxy of 1 to 3 carbon atoms, alkyl of 1 to 3 carbon atoms, methylenedioxy, carboxamido , acetamido or amidino; X is methylene, carbonyl or sulfonyl; Z is methylene, ethylene or propylene; M is methylene or ethylene; and R1, R2, and R3 are independently hydrogen or alkyl of 1 to 3 carbon atoms. |