| abstract |
The invention relates to substituted indolinones of the general formula (I), wherein R1 to R6 and X are defined as in claim 1, to their isomers and salts, in particular their physiologically compatible salts exhibiting valuable pharmacological properties, in particular an inhibition effect on several receptor tyrosine kinases, on several cyclin / CDK complexes and also on the proliferation of endothelial cells and various tumor cells. The invention also relates to medicaments containing these compounds, their use and methods for their production. |