http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MX-PA02000969-A
Outgoing Links
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|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_de50a949527f170e64b086b37edc36af |
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| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-867 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 |
| filingDate | 2000-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_884a464fecea7228fa0365cbcbf3adf6 |
| publicationDate | 2004-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | MX-PA02000969-A |
| titleOfInvention | VACCINE OF HUMAN IMMUNE-DEFICIENCY VIRUS ATTENTION CONTROLLED IN CONDITIONAL FORM. |
| abstract | The present invention provides an attenuated HIV vaccine comprising a modified HIV virus so that it replicates only in the presence of at least one tetracycline analog. Additionally, the present invention provides a method for immunization of humans against HIV which comprises administering to a human a vaccine that includes a modified HIV virus so that it replicates only in the presence of at least one tetracycline analog. Simultaneously, at least one tetracycline analog is administered for a period sufficient to allow replication of the modified HIV virus in vivo in sufficient quantity to produce immunity. Preferably, the tetracycline analog is doxycycline. A competent replication HIV-DoxT virus genome is produced, which can be controlled by the presence or absence of doxycycline by preparing a promoter, TetopTCAT; producing a provirus, pVIH-DoxT, using the TetopCAT promoter, and transfecting pVIH-DoxT in cell lines in the presence of doxycycline. A competent replication HIV-DoxSp virus genome is produced, which can be controlled by the presence or absence of doxycycline by preparing a promoter, TetopSpCAT; producing a provirus, pVIH-DoxSp, using the TetopCAT promoter, and transfecting pVIH-DoxSp in cell lines in the presence of doxycycline. HIV vaccines are prepared using the genomes of HIV-DoxT and HIV-DoxSp viruses. These viruses and doxycycline are administered to human hosts. Doxycycline is administered for a sufficient time to accumulate immunity and then drug administration is stopped so that doxycycline-dependent viruses no longer replicate. |
| priorityDate | 1999-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID454031468 http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID54684461 |
Total number of triples: 36.