| abstract |
The diacylhydrazine derivatives of general formula I (see formula) wherein X, Y, Z, R1, R2 and R3 have the meanings indicated in claim 1, and their physiologically acceptable solvates or salts are inhibitors of integrins and can be used to fight thrombosis, myocardial infarction, coronary heart disease, arteriosclerosis, inflammations, tumors, osteoporosis, infections and recurrent stenosis after an angioplasty, or in the pathological processes that occur. propagate or maintain by angiogenesis. |