abstract |
The heterocyclic compounds represented by the following general formula which have inhibitory effects on AP-1 activity, NF-kappaB activity, production of inflammatory cytokine, production of matrix metalloprotease, expression of inflammatory cell adhesion factor, etc. and are useful as drugs: R1-C (= O) -R2) -AXB- N (R3) -Y- (CH2) n-R4 where Rl represents cycloalkyl or cylcoalkylene; R2 and R3 each represent hydrogen or alkyl; R4 represents alkyl, a heterocycle, etc; n is an integer from 0 to 6; A represents a heterocycle; B represents an aromatic ring or a heterocycle; and X and Y each represent a link or a union group. |