| abstract |
The present invention provides cell lines expressing a recombinant heteromeric glutamate AMPA receptor, preferably a human heteromeric glutamate AMPA receptor, or a recombinant human homomeric glutamate AMPA receptor. The invention also provides methods for preparing said cell lines. The invention also concerns the use of said cell lines for the identification of agonists, antagonists or modulators of the glutamate receptor and of methods for the identification of said agonists, antagonists or modulators. The invention also provides pharmaceutical compositions comprising said agonists, antagonists or modulators. The invention also relates to the use of agonists, antagonists or modulators in the manufacture of a medicament for the treatment of neurological disorders. |