| abstract |
Compounds of the formula (1) and their pharmaceutically acceptable salts are described, wherein m is 0, 1 or 2; n is 2, 3, 4 or 5; X is carbonyl or a group of the formula (11), wherein R5 is H or alkyl; Y is an alkylene chain optionally substituted by one or more alkyl groups; Z is an alkylene chain containing 2 to 5 carbon atoms optionally substituted by one or more alkyl groups; R is phenyl optionally substituted by one or more halo substituents or R is naphthyl; and R, and R2, which are the same or different, are H, alkyl or arylalkyl, provided that when R is benzyl, R2 is H or methyl; and which have utility in the treatment of drug misuse or other addiction disorders. |