http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MX-PA01013341-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0264ab149dd139d522f7f14b1a3ea9e2 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-96 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-96 |
| filingDate | 2000-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a8c3f9fac8ff739fcc5be314b9c8088 |
| publicationDate | 2002-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | MX-PA01013341-A |
| titleOfInvention | NOVEDOUS PROCESS FOR THE PREPARATION OF ESPIRO DERIVATIVES ((4-CICLOHEXANONA) - (3H) INDOL) -2 '- (1'H) ONA. |
| abstract | The invention relates to a process for the preparation of spiro derivatives [(4- cyclohexanone) - [3H] indoll-2 '[1'H] indole] -2' [1'Hl-one of the general formula I -en where R1 and R ° independently mean hydrogen, Cl-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, C1-4 polyfluoroalkyl, C1-4 polyfluoroalkoxy, C3-7 cycloalkyloxy, C3-7i phenoxy cycloalkylthio , benzyloxy or nitro- group, characterized by reacting an indolin-2-one derivative of the general formula II - where Rl and R ° are as defined above - with a compound capable of introducing a protective group, coupling the compound of the general formula 111, thus obtained wherein R1 and R ° are as defined in the foregoing and A means a protective group -with C1-4 ester of acrylic acid, cyclizing the resulting compound of the general formula IV - wherein R1 and R ° are as defined above with a compound capable of introducing a protective group, coupling the compound of the fo Formula III thus obtained, - wherein R1 and R ° are as defined above and A means a protective group - with a C1-4 ester of acrylic acid, cyclizing the resulting compound of formula IV - where Rl and R ° are as defined above, R ° means C1-4 alkyl and A means a protective group -, eliminating the group - COOR ° and the protecting group A from the ketoester of the formula V - where Rl and R ° are as defined in the foregoing, R ° means C1-4 alkyl and A means a protecting group -, optionally without isolation of the compounds of general formulas IV and / or V and / or VI. |
| priorityDate | 1999-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 53.