abstract |
Compounds of the formula (1) (see formula) that are inhibitors of Fab 1 and are useful in the treatment of bacterial infections are exposed, in which: Rl is Ar or Het; R2 is H, C1-6 alkyl or Ar-C0-6 alkyl; X is H, C1-4 alkyl, or OR ', SR', C1-4 alkylsulfonyl, C1-4 alkylsulfoxyl, CN, N (R ') 2, CH2N (R') 2, NO2, CF3, CO2R ', CON (R') 2, COR ', NR'C (O) R', F, CI, Br, 1 or CF3S (O) r-; R 'is H, C1-6 alkyl, or Ar-C0-6 alkyl; and r is 0, 1 or 2; or a pharmaceutically acceptable salt thereof. |