| abstract |
The invention provides novel mutations, combination of mutations or mutational profiles of HIV-1 reverse transcriptase and / or protease genes correlated with phenotypic resistance to HIV drugs; more particularly, the present invention relates to the use of genotypic characterization of a white population of HIV and the subsequent correlation of this information with phenotypic interpretation in order to correlate the mutational profiles of the virus with drug resistance; The invention also relates to methods for using the mutational profiles of the invention in database, drug development, that is, drug design, and drug modification, therapy and treatment design, clinical management and diagnostic analysis. |