| abstract |
A compound of formula (see formula) in which R1, R2, R3, R4 and Q are as defined above, which is useful in the treatment of arthritis (including osteroarthritis and rheumatoid arthritis), cancer and other diseases in addition The compounds of the present invention can be used in combination therapy with non-steroidal anti-inflammatory drugs (NSAIDs), COX-2 inhibitors and conventional analgesics, and in combination with cytotoxic drugs such as adriamycin, daunomycin, cis-platinum, ethoposide, taxo1 , taxotero and other alkaloids, such as vincristine, in the treatment of cancer. |