| abstract |
The use of anticonvulsant derivatives of formula 1 to reduce blood pressure particularly in overweight individuals, where X is CH2 or oxygen, R1 is hydrogen or alkyl; and R2, R3, R4 and R5 are independently hydrogen or alkyl and, when X is CH2, R4 and R5 can be alkene groups joined to form a benzene ring and, when X is oxygen, R2 and R3 and / or R4 and R5 together they can be a methylenedioxy group of formula 11, wherein R6 and R7 are the same or different and are hydrogen, or alkyl and are joined to form a cyclopentyl or cyclohexyl ring. |