http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MX-PA01007323-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e400c7cafe4d27546b9127d5fdd3312b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-32 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-113 |
| filingDate | 2000-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5692e8269a81ebd1fcf914a9b6950549 |
| publicationDate | 2002-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | MX-PA01007323-A |
| titleOfInvention | METHODS TO GENERATE SPECIFIC IMMUNOLOGICAL REAGENTS OF FOSFRILATION SITES. |
| abstract | The present invention provides methods for generating specific immunological reagents from phosphorylation sites. More specifically, a phosphopeptide mimetic is incorporated into a polypeptide instead of a phosphorylated amino acid. The polypeptide is used as an antigen by standard methods to generate monoclonal or polyclonal antibodies that cross-react with the phosphorylated polypeptide naturally. The phosphopeptide mimetic preferably contains a non-hydrolysable bond from the appropriate carbon atom of the amino acid to a phosphate group. A preferred union is a CF2 group. Said binding is used to generate the F2Pab phosphoserine mimetic, which is incorporated into a polypeptide sequence derived from p53 to produce antibodies that recognize a specific phosphorylation state of p53. A CF2 group binding is also used to produce antibodies to produce the F2Pmb phosphotreonin mimetic and to produce the F2PmP phosphotyrosine mimetic. |
| priorityDate | 1999-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.