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filingDate 1999-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f02079e28c7dd23762cbfe7bfdb0f95
publicationDate 2002-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber MX-PA01006461-A
titleOfInvention METHOD FOR PREPARING AN EFFECTIVE GRANULATE THAT INCLUDES IRON GLUCONATE, GRANULATE AS OBTAINED AND TABLETS CONTAINING THE SAME.
abstract A method for preparing an effervescent granulate comprising as pharmacologically active ingredient ferrous gluconate and as an effervescent system, citric acid and sodium bicarbonate, by wet granulation in a fluid bed granulator, characterized in that it comprises the steps of: 1. introducing a mixture comprising ferrous gluconate, citric acid and sodium bicarbonate in said granulator which is simultaneously fed with a flow of air heated to approximately 70 ° C and having a moisture content of <1.0 g / kg; 11. moisten said mixture with water mist when this mixture has reached a temperature of approximately 35 ° C; 111. evaporate the water mist; keeping the temperature of said mixture substantially constant at 35 ° C; IV) repeat steps 11 and 111 until a granulate with the desired characteristics is obtained; and V) drying said granulate with air heated to approximately 80 ° C until its moisture content is <0.5% by weight. Granulate thus obtained and tablets contain the same.
priorityDate 1998-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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