| abstract |
A compound of formula (see formula) in which R1-R13, X, Z and Q are as defined above, useful in the treatment of arthritis, cancer and other diseases that imply the poorly regulated production / release of reprolysins, such as aggrecanase, and other diseases characterized by matrix metalloproteinase activity. In addition, the compounds of the present invention can be used in combination therapy with standard non-steroidal anti-inflammatory drugs (NSAIDs), COX-2 inhibitors and analgesics, and in combination with cytotoxic drugs such as adriamycin, daunomycin, cis-platinum, ethoposide, taxol , taxotero and other alkaloids, such as vincristine, in the treatment of cancer. |