| abstract |
The invention provides novel JAK-3 inhibitors, which are useful for treating leukemia and lymphomas. The compounds are also useful for treating or preventing skin cancer, as well as sunburn and UVB-induced skin inflammation. In addition, the compounds of the present invention prevent the immunosuppressive effects of UVB radiation, and are useful for treating or preventing autoimmune diseases, inflammation and transplant rejection. The invention also provides pharmaceutical compositions comprising compounds of the invention, as well as therapeutic methods for their use. (see formula). |