| abstract |
The present invention relates to amphiphilic pharmaco-oligomer conjugates capable of crossing the blood-brain barrier and methods for making and using said conjugates; amphiphilic pharmaco-oligomer conjugates comprise a therapeutic compound conjugated to an oligomer, characterized in that the oligomer comprises a lipophilic portion coupled to a hydrophilic portion; The conjugates of the invention further comprise therapeutic agents such as proteins, peptides, nucleosides, nucleotides, antiviral agents, antineoplastic agents, antibiotics, etc., and prodrugs, precursors, derivatives and their intermediates, chemically coupled to amphiphilic oligomers. |