http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MX-PA01000826-A
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_45a3703d03a4b21be619937f5ad63b8b |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5011 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5091 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6845 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-25 |
classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-25 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15 |
filingDate | 1999-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf3038192e798d11e0de5874f92c81e7 |
publicationDate | 2002-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | MX-PA01000826-A |
titleOfInvention | SUBFAMILIA OF ARN HELICASAS THAT ARE MODULATORS OF THE FIDELITY OF THE TERM OF TRANSLATION, AND USES OF THE SAME. |
abstract | The present invention provides a method for modulating the efficiency of the term of translation of rRNA and / or promoting the degradation of aberrant transcripts; likewise, this invention provides a method for selecting an active drug that is involved in the improvement of the term of the translation, and a method for identifying a disease state that involves the actin protein complex; This invention provides a purified complex comprising an amount of human MTT1, Upf1p, a peptidyl 1 eukaryotic release factor, eRFl, and a peptidyl 3, eRF3 eukaryotic release factor, effective in modulating the term of translation; furthermore, this invention provides an expression vector comprising a nucleic acid encoding human MTT1, Upf1p, a peptidyl 1 eukaryotic release factor, eRFl, and a peptidyl 3, eRF3 eukaryotic release factor, operably linked to a regulatory element; This invention provides an antibody that binds to the complex comprising an amount of human MTT1, Upf1p, a peptidyl 1 eukaryotic release factor, eRFl, and a peptidyl 3, eRF3 eukaryotic release factor, effective to modulate the term of the translation; This invention provides an agent that inhibits or modulates the binding of MTT1 to eRF3; The agent can inhibit or facilitate the binding of MTT1 to eRF3. |
priorityDate | 1998-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 435.