| abstract |
This invention relates to a compound of the formula: or to a pharmaceutically acceptable salt thereof, each being A and R1 each having an optionally substituted 5- to 6-membered heteroaryl, the heteroaryl being optionally fused to a carbocyclic ring or a 5-heteroaryl. to 6 members; being R2 NH2; R3 and R4 each being hydrogen, halo, alkyl (Cl-C4) optionally substituted with halo and the like; and being from X1 to X4 each hydrogen, halo, hydroxy, alkyl (Cl-C4) optionally substituted with halo and the like; These compounds have COX-2 inhibition activity and are therefore useful for treating and preventing inflammation and other diseases related to COX-2. |