| abstract |
A substituted fused heterocyclic compound is described which is represented by the following formula: (see formula) [wherein R 1 represents a group of the following formula: (see formula) (in which R 4: a substituted phenyl group or a pyridyl which it may have a substituent, R5: a hydrogen atom or the like, R6: a hydrogen atom, a C1-6 alkyl group or the like, D: an oxygen or sulfur atom, E: a CH group or a nitrogen atom , R2: a hydrogen atom or the like, R3: a 2,4-dioxothiazolidin-5-ylmethyl group or the like; A: a C1-6 alkylene group and B: an oxygen or sulfur atom] or a pharmacologically acceptable salt thereof, and which has excellent insulin resistance enhancing action, lipid peroxide production inhibitory action, 5-lipoxygenase inhibitory action and the like. |