| abstract |
Novel and known derivatives of bicyclic 4-aralkylamino-pyrimidine of formula (I), where A is a closed chain of benzene or imidazole; B is a closed chain of benzene, tetralin, indan or 2-oxindole; R is perfluoro (C1-C4) alkylphenyl, phenyl (C1-C4) alkyl, hydroxy-C1-C4 alkyl, C1-C4 alkoxy-C1-C4 alkyl, (C2-C4) acyloxy-alkyl. (C1-C4), halobenzoyloxy-C1-C4-alkyl, carboxy, carbamoyl, C1-C4-alkoxycarbonyl, cyano, C1-C4-alkylcarbonyl, carboxy-C1-C4-alkyl, carbamoyl-C1-alkyl C4), (C1-C4) alkoxycarbonyl-(C1-C4) -alkyl, halo-C1-C4-alkyl, amino-C1-C4-alkyl, mono- or di-C1-C4-alkylamino-C1-alkyl -C4), sulfo-C1-C4-alkyl or sulfamido-C1-C4-alkyl; each of R1 and R2 which may be the same or different is hydrogen, C1-C4 alkyl, C1-C4 alkoxy, halogen or -NR5R6, where each of R5 and R6, which may be the same or different, H or C1-C4 alkyl; and each of R3 and R4, which may be the same or different is, hydrogen, C1-C4 alkyl, halogen, hydroxy, C1-C4 alkoxy, C1-C4 alkoxycarbonyl, nitro, cyano or CF3; as well as the pharmaceutically acceptable salts thereof, they constitute tyrosine kinase inhibitors. |