| abstract |
The invention comprises compounds of formula I and pharmaceutically acceptable salts thereof wherein Ar is an aryl group preferably selected from the group consisting of phenyl, 2-, 3-, or 4-pyridyl, 2- or 3-thienyl, 2 -, 4- or 5-pyrimidyl, each of which is optionally mono or disubstituted with halogen, hydroxyl, lower alkoxy or lower alkyl; B is sulfur, oxygen, N (R5) or C (R5) (R6); or B represents a group of formula II optionally substituted with halogen, hydroxyl, lower alkyl or lower alkoxy; n is 1, 2 or 3, m is 2, 3 or 4, W, X, Y and T are the same or different and represent hydrogen, halogen, hydroxyl, lower alkoxy or lower alkoxy; R1 and R2 are the same or different and represent lower alkyl hydrogen; R3 and R4 are the same or different and represent hydrogen, lower alkyl, or lower alkoxy; R5 represents lower alkyl, phenyl, 2, 3 or 4-pyridyl, phenyl, lower alkyl or 2, 3 or 4-pyridyl, lower alkyl; and A and R6 are the same or different and represent hydrogen, hydroxy, amino, lower alkyl, lower alkoxy, phenyl, optionally substituted benzyloxy, 2, 3 or 4 pyridyl, phenoxy, 2, 3 or 4 pyridyloxy, or (CH2) p -A '- (CH2) qB' where p is 0-5, q is 1-5 and A 'is a direct bond, oxygen or sulfur, and B' is hydrogen, lower alkyl, lower alkoxy, phenyl, 2, 3 or 4 pyridyl, phenoxy, 2, 3 or 4 pyridyloxy, carboxyl, crboalkoxy, carboxamido, mono or dialkylcarboxamido, amino or mono- or dialkylamino. |