http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MX-9709961-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cdfcecb1fb4cbb82a8c723f934e25e92 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-96461 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-96463 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4626 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-745 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-86 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate | 1997-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_041c1780d93f6b95ce02de304b842400 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9391bbb791941f0eb36cc26155493a9 |
| publicationDate | 1998-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | MX-9709961-A |
| titleOfInvention | THROMBOSIS RISK TEST. |
| abstract | The present invention provides a method for determining thrombotic risk in an individual. The method involves determining the activity of Protein C and Protein S in the plasma of the individual who is at thrombotic risk, adding to a plasma sample obtained from the individual: (i) a first reagent in an amount sufficient to induce or activate the coagulation in plasma, (ii) a second reagent, which activates endogenous protein C in plasma, and (iii) a third reagent comprising calcium salts, phospholipids or tissue thrombosplastin, or a combination thereof. To a second plasma sample, from the same subject, a reagent is added, which induces or activates coagulation, and a pH regulator or other material, which does not activate protein C, and a third reagent, as described previously. The time, speed, or both, necessary for the conversion of endogenous fibrinogen or fibrin to both the first and second samples, is measured. The same steps are carried out in normal control plasma, and the difference or relationship in the times, speeds, or both, previously obtained, is determined. The difference or relationship is indicative of the thrombotic risk in the subject. Equipment adapted to carry out the method is also the subject of the present invention. The methods and kits of the invention in other embodiments may comprise a first reagent comprising a synthetic substrate, a second reagent which in the first sample of the subject activates protein C, and in the second sample, a second reagent which does not activate protein C. In these modalities, the rates of hydrolysis of the synthetic substrates are measured and compared. |
| priorityDate | 1995-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.