| abstract |
The present invention relates to derivatives of the general formula (I) having a high affinity for the 5-HT1A receptor, to methods for preparing the same, to pharmaceutical compositions containing the derivatives, and to their use, in particular as inhibitors of gastric acid secretion or as antiemetics. In the general formula (I), Ar is phenyl substituted by one or more substituents; and R is a C1-10 hydrocarbon radical selected from straight or branched alkyl, alkenyl or alkyl radicals, cycloalkyl, cycloalkylalkyl or alkylcycloalkyl, mono- or polycyclic, saturated or unsaturated radicals; a pyridyl or isoquinolyl radical, phenyl optionally substituted by one or more substituents, and salts thereof. |