| abstract |
Compounds of formula I are described, in which X is an optionally substituted phenyl substituted carbonyl, sulfonyl, methionyl or methylene; Z is nitrogen or CH; Ar1 and Ar2 independently represent aryl groups; and Y is hydrogen; or Y and R1 or R2 together represent CH2; CH2CH2; CH2O; CH2S forming a five or six membered ring and such a ring may be optionally substituted with lower alkyl or phenyl; or the pharmaceutically acceptable salts thereof, useful in the treatment of neoplastic diseases, and bacterial or fungal infections, and the prevention or reduction of the production of abnormally phosphorylated helical filament (PHF) epitopes associated with Alzheimer's Disease and , therefore, useful to treat Alzheimer's Disease. |