| abstract |
The invention relates to a process for the preparation of substituted 3-aminobenzonitriles of formula I: (See Formula) where: R is hydrogen or alkyl of 1 to 12 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, COR1 , alkoxy of 1 to 8 carbon-alkyl atoms, hydroxyalkyl of 1 to 6 carbon atoms, aminoalkyl of 1 to 8 carbon atoms, alkyl of 1 to 8 carbon atoms-NH (alkyl of 1 to 4 carbon atoms) , alkyl of 1 to 8 carbon-N atoms (alkyl of 1 to 4 carbon atoms) 2, substituted or unsubstituted benzyl; and R1 is alkyl of 1 to 8 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, or phenyl, and which comprises reacting a substituted 3-aminochlorobenzene of formula II: (See Formula); with a cyano donor reagent. The compounds of formula I are important intermediates in the preparation of benzothiadiazol-7-carboxylic acid, which is obtained by diazotizing and hydrolyzing the compounds of formula I in any desired sequence. |