| abstract |
A compound of formula (I) and its pharmaceutically acceptable salts in which R is hydrogen or hydroxy; Ar is unsubstituted or substituted phenyl; X is unsubstituted or substituted phenyl or heterocyclic, mono-, di-, or trihalomethyl or the like; and X1 is phenyl, naphthyl, furyl, thienyl, pyridyl, thiazolyl, benzofuryl, benzothienyl or the like. These compounds have agonist activity towards the Kappa opiate receptor and are therefore useful as analgesic, anti-inflammatory, diuretic and neuroprotective agents. |