| abstract |
The invention relates to compounds having formula (I), pharmaceutically acceptable addition salts and sterochemically isomeric forms thereof, where Y is CH or N; R1, R2, and R3 are each independently hydrogen or C1-4alkyl; R4 and R5 are each independently hydrogen, halogen, C1-4alkyl; C1-4 alkyloxy; hydroxyl, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; R6 is pyridinyl optionally substituted with up to two C1-4alkyl groups; and (C1-4alkyl) hydroxypyridinyl; and (C1-4alkyl) C1-4alkyloxypyridinyl; pyridyzanyl optionally substituted with C1-4 alkyloxy; pyridinyl optionally substituted with hydroxy or C1-4 alkyloxy; thiazolyl optionally substituted with C1-4alkyl; tquiazolyl optionally substituted with C1-4alkyl; benzoxazolyl or benzothiazolyl; or R6 is pyrazinyl or pyriddazinyl substituted with C1-4alkyl; Z is C = O; and (a) is a radical of formula (a-1), (a-2), (a-3), (a-4), (a-5), (a-6) or (a-7 ); compositions comprising said compounds, procedures for preparing the same and the use of these compounds as a medicine. |