| abstract |
Compound of formula (I): where: n is 0, 1 or 2; y is hydroxyl or XONH-, where X is hydrogen or lower alkyl; R1 is hydrogen or lower alkyl; R2 is hydrogen, lower alkyl, heteroalkyl, aryl, aralkyl, arylheteroalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroalkyl, heteroarylheteroalkyl, heterocycle, heterocyclo-lower alkyl, heterocyclo-lower heteroalkyl or -NR6R7, where R6 and R7 are as described in claims; R3 is hydrogen, lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heteroalkyl, or lower alkoxy; R4 is hydrogen, lower alkyl, cycloalkyl, or cycloalkylalkyl; or R2 and R3 together with the carbons to which they are attached represent a cycloalkyl or heterocycle group; or R3 and R4 together with the carbon to which they are attached represent a cycloalkyl or heterocycle group; and R5 is lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl; or pharmaceutically acceptable salts or respective esters exhibit useful pharmacological properties, in particular for use as matrix metalloprotease inhibitors, particularly for interstitial collagenases. |