http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MX-9606319-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7f82940e47ba7a1188f8e2ffca55e0f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D205-085 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D205-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-0812 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-1804 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D205-085 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D205-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-397 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 |
| filingDate | 1995-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_916d914d55df2621b86f00f93e292da0 |
| publicationDate | 1997-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | MX-9606319-A |
| titleOfInvention | SUBSTITUTED ACETIDINONE COMPOUNDS USEFUL AS HYPOCHOLESTEROLEMIC AGENTS. |
| abstract | Substituted acetidinone hypocholesterolemic agents of formula (I) or a pharmaceutically acceptable salt thereof are presented, wherein: Arl is aryl or R3-aryl, Ar2 is aryl or R4-aryl; R1 is selected from the group consisting of - (CH2) q-, where q is 2-6; - (CH2) eZ- (CH2) r, where Z is -O-, -C (O) -, phenylene, -NR10- or -S (O) 0-Z, e ES 0-5 and r is 0-5 , provided that the sum of e and r is 1-6; (C2-C6 alkenylene) -; and (CH2) f-V- (CH2) g-, where V is C3-C6 cycloalkylene, f is 1-5 and g is 0-5, provided that the sum of f and g is 1-6; R2 is - (lower alkylene) -COR5 or (CH-CH) -COR5; R3 and R4 are independently 1-3 substituents selected from lower alkyl, -OR6, O (CO) R6, -O (CO) OR9, -O (CH2) 1-SOR6, -O (CO) NR6R7, -NR6R7, - NR6 (CO) R7, -NR6 (CO) OR9, -NR6 (CO) NR7R8, -NR6SO2R9, -COOR6, -CONR6R7, -COR6, -SO2NR6R7, S (O) 0-2R9, -0 (CH2) 1- 10-COOR6, -O (CH2) 1-10CONR6R7, - (lower alkylene) -COOR6, -CH = CH-COOR6, -CF3, -CH, -NO2 and halogen; R5 is -OR or -NRR12; R, R6, R7, R8, and R12 are independently selected from hydrogen, lower alkyl, aryl, and aryl substituted lower alkyl; R9 is lower alkyl, aryl or aryl substituted lower alkyl; and R10 is hydrogen, lower alkyl, aryl lower alkyl or -C (O) R6; Also presented are a method of lowering the serum cholesterol level by administering said compounds, alone or in combination with a cholesterol biosynthesis inhibitor, and pharmaceutical compositions containing them. |
| priorityDate | 1994-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.