http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MX-9604017-A

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filingDate 1996-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_72477347e95ebe09f4b902c54e16ebd1
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publicationDate 1997-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber MX-9604017-A
titleOfInvention CEPHALOSPORIN DERIVATIVES AND PROCEDURE FOR THEIR PREPARATION.
abstract The present invention relates to cephalosporin derivatives of the general formula I: wherein R1 is a group chosen from 2-, 3- and 4-hydroxyphenyl, 2- and 3-methoxyphenyl, 4-carboxyphenyl, 4-carbamoylphenyl, 3- trifluoromethylphenyl, 2- and 3-fluoro-phenyl, 3-nitrophenyl, 3-fluoro-4-hydroxyphenyl, 2-fluoro-4-hydroxyphenyl, 3-fluoro-2-hydroxyphenyl, 3-, 4-dihydroxy-phenyl, benzyl, -CHR-phenyl, 3-hydroxybenzyl, 4-amino-benzyl, 2-, 3- and 4-fluorobenzyl, 2-, 3- and 4-methoxybenzyl, 4-nitrobenzyl, 4-carboxybenzyl, 4-trifluoromethylbenzyl, 1-naphthyl and 2-naphthyl, with all hydroxyl, amino, carboxyl, and carbamoyl substituents being optionally substituted, or is halo-mono-substituted pyridinyl, pyrimidyl, di-substituted lower-alkyl pyrazinyl, halo-mono-substituted pyridacinyl, piperidinyl wherein the group amino can be substituted by an acyl, thiadiazolyl, oxo-tetra-hydrofuranyl, thiophenyl group mono-substituted by lower alkoxycarbonyl or carbamoyl, tetr azolyl-lower alkyl, tetrahydrofuranyl-lower alkyl, thiophenyl-lower alkyl or benzimidazolyl-lower alkyl; and R is carboxyl or esterified carboxyl; their easily hydrolyzable esters, pharmaceutically acceptable salts of said compounds and hydrates of the compounds of formula I and their esters and salts, as well as their use and the process for the preparation of these compounds.
priorityDate 1995-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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