| abstract |
A pharmaceutical composition comprising biodegradable and biocompatible microparticles containing 1,2-benzazole of formula (I); or a pharmaceutically acceptable acid addition salt thereof, wherein R is hydrogen or C1-6alkyl; R1 and R2 are independently hydrogen, halogen, hydroxy, C1-6 alkyloxy and C1-6 alkyl; X is O or S; Alc is C1-4 alkanedyl; and R3 is hydrogenon where R4 and R5 are independently hydrogen or C1-6alkyl; A is a bivalent radical -CH2-CH2-, -CH2-CH2-CH2- or -CR6 = CR7-; wherein R6 and R7 are hydrogen, halogen, amino or C1-6alkyl; and R8 is hydrogen or hydroxyl; within a polymer matrix. |