| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-525 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-19 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-525
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 |
| filingDate |
1993-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_10420388d34389399f14d8740678324f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3435fde018ef658aa00ffbb3fc31dbad
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a3cb35e75fdb2eb6137a44f8d0455f5 |
| publicationDate |
1993-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
MX-9301700-A |
| titleOfInvention |
MUTEINS OF THE HUMAN TUMOR NECROSIS FACTOR, PROCEDURE FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. |
| abstract |
The present invention relates to a human tumor necrosis factor mutein or a pharmaceutically acceptable salt thereof, having a selective binding affinity for the human tumor necrosis factor receptor p55 characterized in that the amino acid sequence of necrosis factor Human tumor has been changed to at least position 86 showing a threonine residue instead of a serine residue, a DNA sequence encoding said mutein, a vector comprising said DNA sequence, a host cell transformed by said vector, a method for the production of said muteins by said host cells, pharmaceutical compositions containing said mutein and the use of said mutein for the treatment of diseases. |
| priorityDate |
1992-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |