| abstract |
The present invention relates to a conjugated medicinal agent prepared by combining asialoglycoprotein with a medicine that specifically acts on the liver. The conjugated medicinal agent of the present invention has the following formula (I), in which portion P- (S) X, P is a peptide residue of a human serum glycoprotein and S is a sugar residue of a human serum glycoprotein ; Gal is a galactose residue; GA is a glutaraldehyde residue; x is an integer equal to or greater than 1; and R is a medicinal component selected from a group consisting of interferon, acyclovira sodium, rivavirin, vidarabine, zidovudine, suramide, anti-sensory oligoneuclide, ribocin, leucovorin, calcium, gadolinium-DTPA, glutathione (GSH ), 'prostaglandis', 99mTC and 131I. The present invention also includes a process for preparing the medicinal conjugate agent of formula (I), a pharmaceutical composition containing the conjugated medicine, as well as the use of the medicine. |