| abstract |
Provided herein are pediatric dosage forms for use in treating pediatric cholestatic liver disease by non-systemic administration to an individual in need thereof of a therapeutically effective amount of the pediatric dosage form comprising a transporter inhibitor. apical sodium dependent bile acid (ASBTI) or a pharmaceutically acceptable salt thereof. Such a pediatric dosage form is also provided for use in the treatment of pediatric liver disease, for use in lowering the levels of serum bile acids or hepatic bile acids, for use in the treatment of pruritus, for use in the reduction of liver enzymes or bilirubin comprising non-systemic administration to an individual in need thereof of a therapeutically effective amount of a pediatric formulation comprising an ASBTI or a pharmaceutically acceptable salt thereof. |