http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MX-369438-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dc788dc22d2fff9e51fb63ddf3976055 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4164 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D285-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-00 |
| filingDate | 2013-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6fb5b867fa07ede6fc7ee908744ee3f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7131806bce2d07e9740094ec271362a7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_941761e3a6582aa8d7ac3cc4c02a0e70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76c2402e2bd6acee51e5f14ab57050cf |
| publicationDate | 2019-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | MX-369438-B |
| titleOfInvention | IMIDAZOLINES 8-HEXYLOXIFENIL-2-IMIDAZOLINA, 8-NONYLOXIFENIL-2-IMID AZOLINA, 7-HEXYLOXIFENIL-2-IMIDAZOLINA AND 7-NONYLOXIFENIL-2-IMIDAZO LINA AND ITS PROCESS OF OBTAINING. |
| abstract | The present invention relates to the compounds 7-HEXYLOXIFENIL-2-IMIDAZOLINA AND 7-NONYLOXIPENIL-2-IMIDAZOLINA, and the process to obtain them. These compounds are obtained through a two-step process: an alkylation of the 3-hydroxybenzaldehyde with the corresponding alkyl halide obtaining 81% isolated yield and a cyclization using ethylenediamine, potassium carbonate, triethylamine, iodine and t-butanol, obtaining quantitative yield . The two compounds 7-HEXYLOXIFENIL-2-IMI DAZOLINA AND 7-NONYLOXIFENIL-2- IMIDAZOLINA, have in vitro activity against Trypanosoma cruzi, the compounds have been evaluated on blood trypomastigotes of the NINOA and INC-5 strains and in the latter they present activity practically the same as the clinical drugs Nifurtimox and Benznidazole at concentrations of 19.2 and 38.4 µM. The compounds 7-HEXYLOXIFENIL-2-IMIDAZOLINA AND 7-NONYLOXIFENIL-2-IMIDAZOLINA, due to their chemical characteristics can give rise to molecular gels, which are formed by means of nanoparticles. |
| priorityDate | 2013-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.