| abstract |
The present invention relates to novel compounds of formula (I), wherein R1 is C1-4 alkyl; R2 is C1-4 alkyl, C3-7 cycloalkyl, -CH2CF3, -CH2OCH3, or heterocyclyl; R3 is C1-4 alkyl, -CH2F1 -CH2OH or -CH2O (O) CH3; R4, when present, is as defined in claim 1; R5, when present, is H, halogen, hydroxy or C1-6 alkoxy; A is -NH-, -O-, -S-, -SO-, -SO2-, - N (C1-4 alkyl) - or -NC (O) (CH3) -; V is phenyl, heteroaromatic, or pyridone, any of which may be optionally substituted with 1,2 or 3 substituents; W is CH or N; X is C or N; Y is C or N; and Z is CH or N; subject to the condition that no more than 2 of W, X, Y, and Z are N; pharmaceutical compositions containing said compounds and their use as bromodomain inhibitors (see Formula). |