titleOfInvention |
N-ACIL-5,6,7, (8-SUBSTITUTE) -TETRAHYDRO- [1,2,4] TRIAZOLO [4,3-a] CHIRAL PYRAZINES, NOVELTY, AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS; PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR-MEDIATED DISORDERS AND ITS CHIRAL SYNTHESIS. |
abstract |
The present invention relates to novel compounds of formula I: (see Formula) and their use in therapeutic treatments. The invention further relates to a novel chiral synthesis of 5,6,7, (8-substituted) -tetrahydro- [1,2,4] triazolo [4,3-a] pyrazines using N-sp3 protecting groups. The invention also provides intermediates for use in the synthesis of compounds of formula I. |