http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MX-363787-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_282d8844066f5f683bc2463742373508 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6869 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6855 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6851 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6889 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6803 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-68 |
| filingDate | 2014-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0dd136b7d0ac032a55ca486ddaab9363 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3008ff938f1197fa3d49760e70562068 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_327a5c727a15764d3150115638f6628e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d9520c77f0f8f9daa8495eace013b99 |
| publicationDate | 2019-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | MX-363787-B |
| titleOfInvention | PIRROLOBENZODIAZEPINAS AND CONJUGADOS OF THE SAME. |
| abstract | The present invention relates to conjugate compounds of the formula (A): (see Formula) wherein: R2 is (see formula) where R36a and R36b are independently selected from H, F, saturated C1-4 alkyl, C2- alkylene 3, whose alkyl and alkylene groups are optionally subsisted by a group selected from C1-4 alkyl amido and C1-4 alkyl ester; or, when one of R36a and R36b is H, the other is selected from nitrile and a C1-4 alkyl ester; R6 and R9 are independently selected from H, R, OR, SH, SR, NH2, NHR, NRR ', NO2, ME3SN and halo; R7 is independently selected from H, R, OR, SH, SR, NH2, NHR, NRR ', NO2, ME3SN and halo; and is selected from formulas A1, A2, A3, A4, A5 and A6: (see formulas) L is a linker connected to a cell binding agent; CBA is the cell binding agent; n is an integer selected in the range from 0 to 48; RA4 is a C1-6 alkylene group; any of (a) R10 is H, and R11 is OH, ORA, where RA is C1-4 alkyl or (b) R10 and R11 form a double nitrogen-carbon bond between the nitrogen and carbon atoms to which they are linked; or (c) R10 is H and R11 is OSOZM, where z is 2 or 3 and M is a monovalent pharmaceutically acceptable cation; R and R 'are each independently selected from optionally substituted C1-12 alkyl, C3-20 heterocyclyl and C5-20 aryl groups, and optionally in relation to the NRR', R and R 'group together with the nitrogen atom to which bind form an optionally substituted 4-, 5-, 6- or 7-membered heterocyclic ring; wherein R16, R17, R19, R20, R21 and R22 are as defined for R6, R7, R9, R10, R11 and R2 respectively; where Z is CH or N; wherein T and T '' are independently selected from a single bond or a C1-9 alkylene, whose chain can be interrupted by one or more heteroatoms for example O, S, N (H), NMe, provided that the number of atoms in the shortest chain of atoms between X and X 'is 3 to 12 atoms; and X and X 'are independently selected from O, S and N (H). |
| priorityDate | 2013-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.