| abstract |
The present invention relates to antibodies and antibody-prostate specific membrane antigen (PSMA) conjugates comprising at least one non-naturally encoded amino acid. APSMA antibodies with one or more non-naturally encoded amino acids are described herein and antibody-drug conjugates are further described wherein the aPSMA antibodies of the invention are conjugated to one or more toxins. Dolastatin analogs of non-natural amino acids that are further modified in a post-translational manner, methods for effecting such modifications, and methods for purifying such dolastatin analogs are also described herein. Typically, modified dolastatin analogs include at least one oxime group, carbonyl, dicarbonyl and / or hydroxylamine. Methods for using such antibody-drug conjugates of unnatural amino acids, dolastatin analogues and dolastatin analogs of modified unnatural amino acids, including therapeutic, diagnostic and other biotechnological uses are also described. |