| abstract |
The present invention is directed to compounds of Formula I: (see Formula) wherein ring A is phenyl, nafihalenyl, pyridyl, quinolinyl, isoquinolinyl, imidazopyridyl, furanyl, tlisazolyl, isoxazolyl, pyrazolyl, imidazothiazolyl, benzimidazolyl or indazolyl; R1 is H, alkyl, alkoxy, hydroxyalkylene, OH, halo, phenyl, triazolyl, oxazolyl, isoxazophil, pyridyl, pyrimidinyl, pyrazinyl, pyridazmyl, piperazinyl, pyrazolyl, oxadiazolyl, pyrrolidinyl, thiophenyl, morpholinyl or dialkylamino; R2 is H, alkyl, alkoxy, hydroxyalkylene or halo; Z is NH, N-alkyl or O; R5 is pyridyl, pyrimidinyl, pyrazinyl, pyridazmyl, cumazolinyl, quinoxalinyl, pyrazolyl, benzoxazolyl, imidazopyrazinyl, triazolopyrazinyl, optionally substituted with one or two substituents independently selected from the group consisting of alkyl, alkoxy or halo; and n is 0 or 1; The methods for making the compounds of Formula I are also described; The invention also relates to pharmaceutical compositions comprising compounds of Formula I; The methods of using the compounds of the invention are also within the scope of the invention. |