| abstract |
Methods of manufacturing viloxazine and its various salts, as well as compounds related to viloxazine, such as novel intermediate reaction products and polymorphs thereof are provided herein. In particular, the methods provide a substantially pure API of viloxazine HC1 while avoiding undesirable impurities. The methods are also provided to separate, identify and characterize novel viloxazine polymorphs. Methods for synthesis and identification and characterization of novel viloxazine intermediates are also provided, as well as some important metabolites and precursors of viloxazine metabolites. |