http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MX-356212-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a8e95d5b6b71220515f3878c5f799c0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P23-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P23-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P23-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-26 |
| filingDate | 2013-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d126fb4572add7bddb8ea393ef458aa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2df196fd0fb0587e3bf93e68c4a2e8dc |
| publicationDate | 2018-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | MX-356212-B |
| titleOfInvention | STABILIZED WATER COMPOSTIONS OF NEUROMUSCULAR BLOCK AGENTS. |
| abstract | The present invention relates to an aqueous composition comprising: (i) a quaternary ammonium neuromuscular block agent; and (ii) an excipient selected from a polyhydroxy acid of the following formula: HO-CH2- [CH (OH)] n-COOH, wherein n is an integer from 1 to 8, an intramolecular lactone of said polyhydroxy acid or a mixture thereof. Additionally, the present invention relates to a liquid pharmaceutical composition comprising or consisting of said aqueous composition and a method of producing said aqueous composition comprising the steps of: a) providing a quaternary ammonium neuromuscular block agent, wherein said neuromuscular block of quaternary ammonium is optionally freeze-dried, b) provide an excipient selected from a polyhydroxy acid of the following formula: HO-CH2- [CH (OH)] n-COOH, wherein n is an integer from 1 to 8 , an iritramolecular lactone of said polyhydroxy acid or a mixture thereof, wherein said excipient is optionally freeze dried, c) mixing the quaternary ammonium neuromuscular block agent step a) and the passage excipient b) in water to give an aqueous composition. Further, the present invention relates to the use of a polyhydroxy carboxylic acid of the following formula: HO-CH2- [CH (OH)] n-COOH, wherein n is an integer from 1 to 8, an intramolecular lactone of said acid polyhydroxy or a mixture thereof to stabilize an aqueous composition comprising a quaternary ammonium neuromuscular block agent. The present invention also relates to a container containing the aqueous composition or the liquid pharmaceutical composition of the present invention. Additionally, it refers to a kit comprising said compositions. Preferred embodiments are apparent from the dependent claims. |
| priorityDate | 2012-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.