| abstract |
A fluorine-containing amino acid prodrug is provided represented by the general formula (I) which causes a fluorine-containing amino acid that is a group 2 metabotropic glutamate agonist in a prodrug, or a pharmaceutically acceptable salt thereof; more specifically, a prodrug is provided that increases exposure in vivo and improves oral absorption and other mucosal absorption capacity of a compound of origin that acts on group 2 metabotropic glutamate receptors as an agent for treatment or prevention. of the diseases in which group 2 metabotropic glutamate receptors are said to be involved, such as: schizophrenia, anxiety disorder and its related diseases, depression, bipolar disorder, epilepsy, developmental disorders, sleep disorders and other neuropsychiatric diseases ; and drug dependence, cognitive disorders, Alzheimer's disease, Huntington's Korea, Parkinson's disease, movement disorders associated with muscle stiffness, cerebral ischemia, cerebral insufficiency, spinal cord disorders, cephalopathy and other neurological diseases. (see Formula). |